Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms18112334
Keywords
sleep; zinc; nutrition; brain; randomized controlled trial
Funding
- JSPS KAKENHI Grant [JP16K18698, JP16H01881]
- World Premier International Research Center Initiative (WPI) from MEXT
- Grants-in-Aid for Scientific Research [16K18698] Funding Source: KAKEN
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While zinc is known to be important for many biological processes in animals at a molecular and physiological level, new evidence indicates that it may also be involved in the regulation of sleep. Recent research has concluded that zinc serum concentration varies with the amount of sleep, while orally administered zinc increases the amount and the quality of sleep in mice and humans. In this review, we provide an exhaustive study of the literature connecting zinc and sleep, and try to evaluate which molecular mechanism is likely to be involved in this phenomenon. A better understanding should provide critical information not only about the way zinc is related to sleep but also about how sleep itself works and what its real function is.
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