Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 50, Pages 6866-6869Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc01251c
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An efficient and functional group tolerant route to access hydroxy 1,8-naphthalimides has been used to synthesise a range of mono- and disubstituted hydroxy-1,8-naphthalimides with fluorescence emissions covering the visible spectrum. The dialkoxy substituted compounds prepared possess high quantum yields (up to 0.95) and long fluorescent lifetimes (up to 14 ns). The method has been used to generate scriptaid analogues that successfully inhibit HDAC6in vitrowith tubulin acetylation assays confirming that these compounds are more effective than tubastatin.
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