4.7 Article

Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 50, Pages 6882-6885

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc01850c

Keywords

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Funding

  1. ERC [772817]
  2. FCT/MCTES [PD/59/2013 - PD/BD/113807/2015, 1306_2018, ROTEIRO/0028/2013, LISBOA-01-0145-FEDER-022125]
  3. [PTDC/NAN-MAT/30595/2017]
  4. Fundação para a Ciência e a Tecnologia [PTDC/NAN-MAT/30595/2017] Funding Source: FCT

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The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.

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