Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 24, Pages 4628-4637Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob00586j
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21102134, 21172200]
Ask authors/readers for more resources
A simple and efficient protocol for palladium-catalyzed C8-H alkoxycarbonylation of 1-naphthylamine derivatives with alkyl chloroformates has been developed, exhibiting broad functional group tolerance, high regioselectivity, and oxidant-free conditions. Furthermore, the reaction features its ease of further functionalization and transformation. For example, the concise synthesis of one BET bromodomain inhibitor was accomplishedviabenz[cd]indol-2(1H)-one after multistep transformations from the obtained alkoxycarbonylation product. In addition, the control experiments suggest that the reaction might involve a radical process and the C-H bond cleavage might not be involved in the rate-determining step.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available