Journal
NANOSCALE
Volume 12, Issue 25, Pages 13548-13557Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr02800b
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Funding
- National Science Foundation of China [81901882, 31871005, 31900981]
- China Postdoctoral Science Foundation [2019M663062]
- Key Research Program of Frontier Sciences, CAS [QYZDY-SSW-SMC013]
- National Key Research and Development Program of China [2017YFA0205501, 2017YFA0205503]
- Chinese Academy of Sciences [YJKYYQ20180048]
- Education Department of Henan Province [20A430026]
- Youth Innovation Promotion Association CAS [2019093]
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Tumor hypoxia compromises the effects of photodynamic therapy that consumes oxygen in the therapeutic process. Herein, a platinum (Pt)-carbon-integrated nanozyme with favorable catalase-like activity and photosensitizing properties was successfully constructed by immobilizing an ultrasmall Pt nanozyme into a MOF-derived carbon nanozyme through anin situreduction strategy. The integration of a Pt nanozyme significantly improves the catalase activity of a carbon nanozyme that can effectively catalyze the decomposition of endogenous hydrogen peroxide to produce oxygen to improve the effects of photodynamic therapy. In addition, the integration of a Pt nanozyme also enhances the intrinsic photothermal performance of a carbon nanozyme. Combining the improved catalase-like activity with the enhanced photothermal properties together, the Pt-carbon nanozyme exhibits remarkable tumor inhibition abilityin vivo. Thus, utilizing the enzymatic activity and photothermal/photosensitizing properties of nanozymes has great potential to overcome the limitations of traditional therapeutic strategies, and could inspire new directions for nanozyme-based biomedical applications.
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