Journal
MATERIALS CHEMISTRY FRONTIERS
Volume 4, Issue 7, Pages 2064-2071Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qm00170h
Keywords
-
Funding
- National Natural Science Foundation of China [21975149, 21672135, 21402115, 51403122]
- Natural Science Foundation of Shaanxi Province [2018JM5086]
- Fundamental Research Funds for the Central Universities [GK201902006, GK202003036]
- Funded Projects for the Academic Leaders and Academic Backbones, Shaanxi Normal University [18QNGG007]
Ask authors/readers for more resources
Mitochondria-targeted photosensitization provides a facile yet precise therapeutic modality in photodynamic therapy (PDT). Herein, we report two cationic luminogens (TPE-QN and TPE-DQN) with aggregation-induced emission (AIE) characteristics by integrating the tetraphenylethylene group with the quinolinium unit. By expanding the molecular pi-conjugation, the emission of TPE-DQN was successfully red-shifted to 650 nm with a large Stokes shift (similar to 200 nm). Benefiting from good biocompatibility as well as a suitable cationic feature, both AIE luminogens (AIEgens) were able to specifically stain the mitochondria in cancer cells, which enabled them to distinguish cancer cells over normal cells. Both AIEgens also exhibited a high signal-to-noise ratio even without a washing step and excellent photostability. Moreover, TPE-QN and TPE-DQN generated singlet oxygen (O-1(2)) efficiently under white light irradiation while the(1)O(2)generation efficiency of TPE-DQN was as high as 0.83. The selective cancer cell targeting and high(1)O(2)generation efficiency allowed TPE-DQN to be an excellent therapeutic agent for image-guided PDT in cancer cell ablation and tumor inhibition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available