Journal
JOURNAL OF TISSUE ENGINEERING
Volume 11, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/2041731420933407
Keywords
3D culture; tumor model; cancer stem cells; biomaterials; tumor biology
Categories
Funding
- National Natural Science Foundation of China [81760531]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2018R1D1A1B07048459, 2019R1A6A1A11034536]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education (Global Research Development Center Program) [2018K1A4A 3A01064257]
- National Research Foundation of Korea [2018R1D1A1B07048459] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Cancer stem cells have been shown to be important in tumorigenesis processes, such as tumor growth, metastasis, and recurrence. As such, many three-dimensional models have been developed to establish anex vivomicroenvironment that cancer stem cells experience underin vivoconditions. Cancer stem cells propagating in three-dimensional culture systems show physiologically related signaling pathway profiles, gene expression, cell-matrix and cell-cell interactions, and drug resistance that reflect at least some of the tumor properties seenin vivo. Herein, we discussed the presently available Cancer stem cell three-dimensional culture models that use biomaterials and engineering tools and the biological implications of these models compared to the conventional ones.
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