Journal
ACS APPLIED NANO MATERIALS
Volume 3, Issue 6, Pages 5008-5013Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.0c01167
Keywords
superparamagnetic iron oxide nanoparticles; mesenchymal stem cells; in vivo protein delivery; temperature-sensitive polymer; magnetic protein release; polymer-coated nanoparticles
Funding
- EPSRC [EP/M508196/1, EP/K504014/1]
- EPSRC [EP/K504014/1] Funding Source: UKRI
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Nanoparticles could conceal bioactive proteins during therapeutic delivery, avoiding side effects. Superparamagnetic iron oxide nanoparticles (SPIONs) coated with a temperature-sensitive polymer were tested for protein release. We show that coated SPIONs can entrap test proteins and release them in a temperature-controlled manner in a biological system. Magnetically heating SPIONs triggered protein release at bulk solution temperatures below the polymer transition. The entrapped growth factor Wnt3a was inactive until magnetically triggered release, upon which it could increase mesenchymal stem cell proliferation. Once the polymer transition will be chemically adjusted above body temperature, this system could be used for targeted cell stimulation in model animals and humans.
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