Journal
DIABETES & METABOLISM JOURNAL
Volume 44, Issue 3, Pages 446-457Publisher
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2019.0110
Keywords
Body composition; Insulin resistance; Muscles; Sarcopenia; Tomography; X-ray computed
Categories
Funding
- Korea Health Technology RD Project [HI13C0715]
- Ministry of Health and Welfare of the Republic of Korea
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Background: We examined the associations between thigh muscle area (TMA) and insulin resistance (IR) according to body mass index (BMI) in middle-aged Korean general population. Methods: TMA was measured using quantitative computed tomography and corrected by body weight (TMA/Wt) in 1,263 men, 788 premenopausal women, and 1,476 postmenopausal women all aged 30 to 64 years. The tertiles of TMA/Wt were calculated separately for men and for premenopausal and postmenopausal women. Homeostatic model assessment for insulin resistance (HOMA-IR) was performed using fasting blood glucose and insulin levels, and increased IR was defined according to sex-specific, top quartiles of HOMA-IR. Associations between the TMA/Wt tertiles and increased IR according to the BMI categories (< 25 and >= 25 kg/m(2)) were assessed using multivariable logistic regression analysis. Results: In men with higher BMIs, but not in those with lower BMIs, the presence of an increased IR had significantly higher odds ratios in the lower TMA/Wt tertiles, even after adjustment for visceral fat area. However, in premenopausal and postmenopausal women, there was no significant inverse association between TMA/Wt tertiles and increased IR, regardless of BMI category. Conclusion: Our findings suggest that the thigh muscle is inversely associated with IR in men, particularly in those with higher BMIs.
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