Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 14, Issue 12, Pages 1263-1267Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.21023
Keywords
Human prostate cancer; Gleason score; Endothelial cell specific molecule 1; Androgen Receptor
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Funding
- Chung Shan Medical University
- Cheng-Ching General Hospital, Taiwan [CSMU-CCGH-104-01]
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Endothelial cell-specific molecule 1 (ESM1) is a major prognostic marker of several tumor types, but its value as a marker for prostate cancer is unknown. The purpose of the present study was to measure the relationship of ESM1 expression with androgen receptor (AR) expression and with Gleason score in human prostate carcinoma tissue. Expression of ESM1 and AR were determined by immunohistochemical staining of prostate tissues from healthy individuals and patients with prostate cancer. The results showed that ESM1 expression was significantly higher in prostate tumor tissues than in normal prostate tissues (p < 0.01), and that ESM1 expression in prostate tumor tissue correlated with Gleason score (p < 0.016) and Gleason grade (p < 0.013). ESM1 expression was also greater in prostate tissues with higher Gleason score and Gleason grade (p < 0.001 for both comparisons), and also correlated with AR expression (R = 0.727, p < 0.001). In conclusion, our results demonstrated that ESM1 should be considered as a marker for the diagnosis of prostate cancer.
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