Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 31, Issue -, Pages 1-6Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2014.05.004
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Funding
- Wellcome Trust [088130/Z/091Z]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre [088130/Z/09/Z]
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This review surveys recent trends in the use of local field potentials - and their non-invasive counterparts to address the principles of functional brain architectures. In particular, we treat oscillations as the (observable) signature of context-sensitive changes in synaptic efficacy that underlie coordinated dynamics and message-passing in the brain. This rich source of information is now being exploited by various procedures like dynamic causal modelling to test hypotheses about neuronal circuits in health and disease. Furthermore, the roles played by neuromodulatory mechanisms can be addressed directly through their effects on oscillatory phenomena. These neuromodulatory or gain control processes are central to many theories of normal brain function (e.g. attention) and the pathophysiology of several neuropsychiatric conditions (e.g. Parkinson's disease).
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