Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 30, Issue -, Pages 139-143Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2014.12.004
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Funding
- National Institutes of Health [MH070727]
- Intramural Research Program of the National Institute of Mental Health/National Institutes of Health
- National Alliance for Research on Schizophrenia and Depression Independent Investigator Award
- Brain and Behavior Foundation Award
- International Mental Health Research Organization
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In the past decade the emergence of glutamate N-methyl-D-aspartate (NMDA) receptor blockers such as ketamine as fast-acting antidepressants fostered a major conceptual advance by demonstrating the possibility of a rapid antidepressant response. This discovery brings unique mechanistic insight into antidepressant action, as there is a substantial amount of basic knowledge on glutamatergic neurotransmission and how blockade of NMDA receptors may elicit plasticity. The combination of this basic knowledge base and the growing clinical findings will facilitate the development of novel fast acting antidepressants.
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