Journal
NEW JOURNAL OF CHEMISTRY
Volume 44, Issue 26, Pages 11006-11012Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj01564d
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Funding
- Department of Science and Technology (DST) of South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [62620]
- National Research Foundation (NRF) of South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [62620]
- ISRR grant [119259]
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Two readily synthesized water-soluble Sn(iv) porphyrins have been prepared with quaternized pyridyl nitrogens and 2-naphthalatotrans-axial ligands. Methyl and hexyl groups were attached to the quaternized nitrogens to form lipophilic dyes with high singlet oxygen quantum yields (ca.0.90) and unusually long triplet state lifetimes. The dyes exhibit good photodynamic activity against MCF-7 cells with IC(50)values of 14.3 and 8.5 mu M, respectively. The hexyl quaternized dye exhibited a 9.69 log reduction value (0.5 mu M) towardsS. aureusunder illumination for 90 min (250 mW cm(-2)). The results demonstrate that this set of structural modification strategies for photosensitizer dyes merits further in depth study.
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