Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 7, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2020.1761242
Keywords
Energy stress; ferroptosis; AMP-activated protein kinase; acetyl-CoA carboxylase; polyunsaturated fatty acid
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Funding
- National Institutes of Health [CA181196]
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Energy stress disturbs cellular homeostasis and induces cell death. Our recent study revealed that ferroptosis (a non-apoptotic cell death) is an energy-requiring process, and energy stress-mediated activation of adenosine monophosphate-activated protein kinase (AMPK) inhibits ferroptosis. Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis.
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