Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 23, Issue -, Pages 94-101Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2014.11.009
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Funding
- NIH [T32 GM07240]
- NIAID [R01 AI087528]
- Searle Scholars Program
- Packard Foundation
- Burroughs Wellcome Fund fellowship
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Epithelial cells line the surfaces of the body, and are on the front lines of defense against microbial infection. Like many other metazoans, the nematode Caenorhabditis elegans lacks known professional immune cells and relies heavily on defense mediated by epithelial cells. New results indicate that epithelial defense in C. elegans can be triggered through detection of pathogen-induced perturbation of core physiology within host cells and through autophagic defense against intracellular and extracellular pathogens. Recent studies have also illuminated a diverse array of pathogenic attack strategies used against C. elegans. These findings are providing insight into the underpinnings of host/pathogen interactions in a simple animal host that can inform studies of infectious diseases in humans.
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