Journal
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
Volume 39, Issue 2, Pages 129-136Publisher
WILEY
DOI: 10.1111/ijlh.12594
Keywords
Immune system; acute myeloid leukemia; immunosurveillance
Categories
Funding
- Stanford Department of Pathology
Ask authors/readers for more resources
IntroductionWhile the role of the immune system in altering and modulating the progression of solid tumors is well studied, the impact of the immune system on the outcome and progression of hematolymphoid neoplasms is still poorly understood. MethodsHere, we report a retrospective study detailing our analysis of 130 patients with acute myeloid leukemia (AML), with flow cytometry immunophenotypic evaluation of major lymphocyte subsets including B cells, T cells, and NK cells. ResultsOur study identifies differential signatures of lymphocyte subsets pertaining to distinct subcategories of AML, and prognostic correlations in patients. In multivariate analysis, NK cells (specifically CD56+/CD16+ NK cells at a cutoff of 5%) were found to be an independent indicator of improved overall and disease-free survival; cytogenetic risk was also shown to be critical in stratifying patients with AML. ConclusionsIn total, we demonstrate that in AML, the subset distribution of immune system lymphocytes is nonrandom, and suggest an important role for distinct lymphocyte subsets, particularly NK cells, in this disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available