Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 27, Issue -, Pages 62-68Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2015.07.008
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Funding
- NIAID [AI112262, AI116410, P50 GM082250, P01 AI090935, P50 GM081879, P01 AI091575, DARPA-10-93-Prophecy-PA-008, R01 DA033773, P01 HL089707, U19 AI106754, R01 GM084279, P01 CA177322-01A1]
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Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications. Here, we highlight the importance of harnessing genetic diversity of hosts and pathogens for uncovering the biochemical basis of pathogen restriction, virulence, fitness, and pathogenesis. We further suggest that integrating physical interaction data with orthogonal types of data will allow researchers to draw meaningful conclusions both for basic and translational science.
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