Journal
NANOSCALE
Volume 12, Issue 26, Pages 13948-13957Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr01073a
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Funding
- Strategic Priority Research Program of the CAS [XDB20000000]
- National Natural Science Foundation [81572944, 81971983, 21804134]
- Fujian Natural Science Foundation [2019J05157]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- FJIRSM [RHZX-2018-004]
- IUE [RHZX-2018-004]
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Extensively drug-resistant Acinetobacter baumannii (XDR-AB) has raised considerable concerns due to its mortal damage to humans and its high transmission rate of infections in hospitals. However, current antibiotics not only show poor anti-infection effects in vivo but also frequently cause high nephrotoxicity and neurotoxicity. Herein, we report a near-infrared (NIR) light-initiated antimicrobial photodynamic therapy (aPDT) to effectively treat in vivo XDR-AB infections based on photosensitizer (PS) loaded upconversion nanoparticles (UCNPs, LiYF4:Yb/Er). Such nanoagents feature robust NIR triggered UC luminescence and high-efficiency energy transfer from UCNPs to the loaded PS, thereby allowing NIR-triggered generation of reactive oxygen species (ROS) for destroying the bacterial cell membrane. This strategy permits a high antibacterial activity against XDR-AB, resulting in a decline of 4.72 log(10) in viability at a dose of 50 mu g mL(-1) UCNPs-PVP-RB with 980 nm laser irradiation (1 W cm(-2)). More significantly, we can achieve excellent therapeutic efficacy against deep-tissue (about 5 mm) XDR-AB infections without causing any side effects in the murine model. In brief, such NIR-activated aPDT may open up new avenues for treating various deep-tissue intractable infections.
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