Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 23, Issue -, Pages 86-93Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2014.11.008
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- NSERC
- Ontario Lung Association-Pfizer
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The intracellular pathogen Legionella pneumophila (Lp) survives and replicates inside a specialized vacuolar compartment that evades canonical phagosomal maturation. Through the action of a large number of effectors translocated into the host cytosol via the Dot/lcm type IV secretion system, Lp subverts host cell pathways to convert its nascent phagosome into an ER-derived compartment, the Legionella containing vacuole (LCV), which serves as bacterial replication niche.
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