☆ 4.8 Article

The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model

NANOSCALE (2020)

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Journal

NANOSCALE
Volume 12, Issue 16, Pages 8720-8726

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr00867b

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Categories

Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied

Funding

  1. National Key Research and Development Program of China [2016YFC1100403]
  2. National Natural Science Foundation of China [31971265, 31771037, 31971257]

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Magnetic hydroxyapatite (MHA) scaffolds promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitin, ATP and reactive oxygen species decreased in the osteoclast-derived exosomal cargo with MHA stimulation, while Rho kinase increased.

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