Journal
NANOSCALE
Volume 12, Issue 16, Pages 9124-9132Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nr09816j
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Funding
- National Science Foundation Graduate Research Fellows Program [1746053]
- National Science Foundation [CAREER DMR-1654405]
- Welch Foundation [AT-1989-20190330]
- Division Of Graduate Education
- Direct For Education and Human Resources [1746053] Funding Source: National Science Foundation
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The emergence of viral nanotechnology over the preceding two decades has created a number of intellectually captivating possible translational applications; however, thein vitrofate of the viral nanoparticles in cells remains an open question. Herein, we investigate the stability and lifetime of virus-like particle (VLP) Q beta-a representative and popular VLP for several applications-following cellular uptake. By exploiting the available functional handles on the viral surface, we have orthogonally installed the known FRET pair, FITC and Rhodamine B, to gain insight of the particle's behaviorin vitro. Based on these data, we believe VLPs undergo aggregation in addition to the anticipated proteolysis within a few hours of cellular uptake.
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