Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 34, Issue -, Pages 22-27Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.12.009
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- Intramural Research Program of the National Institutes of Health
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Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFN gamma-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.
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