Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 36, Issue -, Pages 67-72Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2015.07.003
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Funding
- NIH [HL076746, DK094641, DK101064, DP1AR064158]
- American Heart Association Innovative Science Award [14ISA20850001]
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Adipose tissue resident leukocytes are often cast solely as the effectors of obesity and its attendant pathologies; however, recent observations have demonstrated that these cells support and effect 'healthy' physiologic function as well as pathologic dysfunction. Importantly, these two disparate outcomes are underpinned by similarly disparate immune programs; type 2 responses instruct and promote metabolic normalcy, while type 1 responses drive tissue dysfunction. In this Review, we summarize the literature regarding type 2 immunity's role in adipose tissue physiology and allude to its potential therapeutic implications.
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