Journal
BIOMATERIALS SCIENCE
Volume 8, Issue 14, Pages 3844-3855Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0bm00533a
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Funding
- National Natural Science Foundation of China [51672247, 51902288]
- Provincial Key Research Program of Zhejiang Province [2020C04005]
- '111' Program - Education Ministry of China
- Sate Bureau of Foreign Experts Affairs [B16043]
- Fundamental Research Funds for the Central Universities
- ZJU-Hangzhou Global Scientific and Technological Innovation Center
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Nanoparticles presenting promoted catalytic activity, oxygen induction and loading capability are in high demand for effective synergistic tumor therapy. Herein, ferric-tannic acid complex nanocapsules with fine hollow microstructure (HFe-TA) are synthesized and loaded with a photosensitizer (indocyanine green, ICG) for synergistic tumor therapy. In acidic environment, ICG@HFe-TA decomposes and releases Fe(3+)ions, TA and ICG molecules. Fe3+, with low catalytic activity, is effectively converted into highly catalytic Fe(2+)by the reductant TA, enabling promoted efficacy of & x2d9;OH induction. More importantly, the ROS (O-1(2)) induction by ICG is significantly enhanced under 808 nm laser irradiation due to the O(2)byproduct of Fe3+/Fe(2+)conversion. In consequence, the ICG@HFe-TA nanoparticles exhibit considerablein vitroandin vivotumor inhibition owing to the combined effect of & x2d9;OH and(1)O(2)induced intracellularly. This study has therefore demonstrated a potential platform enabling combined photodynamic and chemodynamic therapy with high efficacy.
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