Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 33, Issue -, Pages 64-69Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2015.01.017
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology in Japan
- Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST)
- Secom Science and Technology Foundation
- RIKEN Special Postdoctoral Researchers Program
- Grants-in-Aid for Scientific Research [26221306] Funding Source: KAKEN
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Long-lived plasma cells, which mostly reside in the bone marrow have been shown to be vital for protection from recurrent infections. Recent gene-targeting and cell-ablation experiments have solidified the concept that their survival depends on both cell-intrinsic programs and extrinsic factors. The BTB transcription factor ZBTB20, which is expressed at high levels in long-lived plasma cells, is critical for their survival. On the other hand, eosinophils, megakaryocytes and monocytes function to establish a niche for long-lived plasma cells by secreting cytokines and growth factors such as APRIL and IL6.
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