Journal
JOURNAL OF CANCER
Volume 11, Issue 17, Pages 5236-5244Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.46200
Keywords
hyperuricemia; cancer risk; metabolic syndrome; liver metastasis; uric acid-lowering agents
Categories
Funding
- Health and Family Planning Commission of Zhejiang Province [2015RCB026]
Ask authors/readers for more resources
In recent years, metabolic syndrome (Mets) has been a hot topic among medical scientists. Mets has an intimate relationship with the incidence and development of various cancers. As a contributory factor of Mets, hyperuricemia actually plays an inseparable role in the formation of various metabolic disorders. Although uric acid is classically considered an antioxidant with beneficial effects, mounting evidence indicates that a high serum uric acid (SUA) level may serve as a pro-oxidant to generate inflammatory reactions and oxidative stress. In this review, we describe the unrecognized role of hyperuricemia in cancer development and summarize major mechanisms linking uric acid to carcinogenesis. Furthermore, we also discuss the potential mechanism of liver metastasis of cancer and list some types of uric acid-lowering agents, which may exert anticancer effects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available