Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 32, Issue -, Pages 98-105Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2015.01.011
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Funding
- Department of Pediatrics, School of Medicine and Public Health
- Translational Research Pilot Award from the Institute for Clinical and Translational Research
- Stem Cell & Regenerative Medicine Center at the University of Wisconsin, Madison
- March of Dimes [6-FY10-339]
- Wisconsin Partnership Program Collaborative Research Award [2900]
- [NHLBI-RO1HL097134]
- [NHLBI-RO1HL113870]
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Each of the steps of respiratory system development relies on intricate interactions and coordinated development of the lung epithelium and mesenchyme. In the past, more attention has been paid to the epithelium than the mesenchyme. The mesenchyme is a source of specification and morphogenetic signals as well as a host of surprisingly complex cell lineages that are crucial for normal lung development and function. This review highlights recent research focusing on the mesenchyme that has revealed genetic and epigenetic mechanisms of its development in the context of other cell layers during respiratory lineage specification, branching morphogenesis, epithelial differentiation, lineage distinction, vascular development, and alveolar maturation.
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