Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 34, Issue -, Pages 46-53Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2015.07.004
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- Deutsche Forschungsgemeinschaft [CRC1080]
- Belgian Science Policy Office [P7/20 Wibrain]
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Life-long neurogenesis is highly restricted to specialized niches in the adult mammalian brain and therefore the brain's capacity for spontaneous regeneration is extremely limited. However, recent work has demonstrated that under certain circumstances parenchymal astrocytes and NG2 glia can generate neuronal progeny. In the striatum, stroke or excitotoxic lesions can reawaken in astrocytes a latent neurogenic program resulting in the genesis of new neurons. By contrast, in brain areas that fail to mount a neurogenic response following injury, such as the cerebral cortex, forced expression of neurogenic reprogramming factors can lineage convert local glia into induced neurons. Yet, injury-induced and reprogramming-induced neurogenesis exhibit intriguing commonalities, suggesting that they may converge on similar mechanisms.
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