Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 105, Issue 4, Pages 419-422Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12185-017-2199-z
Keywords
Exosomes; miRNA-140-3p; Chronic myeloid leukemia; Musculoskeletal pain; Discontinuation of TKIs
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Funding
- JSPS KAKENHI [JP15H04303]
- Private University Strategic Research-Based Support Project from the Japanese Ministry of Education, Culture, Sports, Science and Technology [S1311016]
- Grants-in-Aid for Scientific Research [17K15656, 15H04303, 16K07183, 15K06841] Funding Source: KAKEN
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We analyzed the exosomal miRNA from peripheral blood from CML patients with musculoskeletal pain after stopping tyrosine kinase inhibitors to identify possible factors related to this manifestation. Exosomal miRNA profiling using TaqMan low-density array revealed that exosomal miR-140-3p was significantly elevated in CML patients showing musculoskeletal pain, when compared to those without such pain (P = 0.0336) or healthy individuals (P = 0.0022). All five CML patients with musculoskeletal pain and increased exosomal miR-140-3p levels sustained deep molecular responses: four of them achieved symptom relief and a significant decrease in exosomal miR-140-3p levels was evident. Because exosomal miR-140-3p is considered to have an inflammation-associated biological function in airway smooth muscle cells and targets Myomarker muscle-specific transmembrane protein, it appears that its overexpression in circulating exosomal miR-140-3p may have some role in the mechanism underlying self-limited musculoskeletal pain.
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