Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 35, Issue -, Pages 93-99Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2015.10.005
Keywords
-
Categories
Funding
- National Science Foundation [DEB-1208741]
- National Institute of Health [1R15GM113177]
- Direct For Biological Sciences
- Division Of Environmental Biology [1208741] Funding Source: National Science Foundation
Ask authors/readers for more resources
Genome architecture varies considerably among eukaryotes in terms of both size and structure (e.g. distribution of sequences within the genome, elimination of DNA during formation of somatic nuclei). The diversity in eukaryotic genome architectures and the dynamic processes are only possible due to the well-developed epigenetic toolkit, which probably existed in the Last Eukaryotic Common Ancestor (LECA). This toolkit may have arisen as a means of navigating the genomic conflict that arose from the expansion of transposable elements within the ancestral eukaryotic genome. This toolkit has been coopted to support the dynamic nature of genomes in lineages across the eukaryotic tree of life. Here we highlight how the changes in genome architecture in diverse eukaryotes are regulated by epigenetic processes, such as DNA elimination, genome rearrangements, and adaptive changes to genome architecture. The ability to epigenetically modify and regulate genomes has contributed greatly to the diversity of eukaryotes observed today.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available