Journal
CURRENT OPINION IN GASTROENTEROLOGY
Volume 31, Issue 5, Pages 395-399Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOG.0000000000000195
Keywords
acute pancreatitis; chronic pancreatitis; high mobility group box 1; macrophages; toll-like receptor
Categories
Funding
- Robert Wood Johnson Foundation
- National Institutes of Health [DK092421]
Ask authors/readers for more resources
Purpose of review This report reviews recent animal model and human studies associated with inflammatory responses in acute and chronic pancreatitis. Recent findings Animal model and limited human acute and chronic pancreatitis studies unravel the dynamic nature of the inflammatory processes and the ability of the immune cells to sense danger and environmental signals. In acute pancreatitis, such molecules include pathogen-associated molecular pattern recognition receptors such as toll-like receptors, and the more recently appreciated damage-associated molecular pattern molecules or 'alarmin' high mobility group box 1 and IL-33. In chronic pancreatitis, a recent understanding of a critical role for macrophage-pancreatic stellate cell interaction offers a potential targetable pathway that can alter fibrogenesis. Microbiome research in pancreatitis is a new field gaining interest but will require further investigation. Summary Immune cell contribution to the pathogenesis of acute and chronic pancreatitis is gaining more appreciation and further understanding in immune signaling presents potential therapeutic targets that can alter disease progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available