Journal
DRUG DISCOVERIES AND THERAPEUTICS
Volume 14, Issue 3, Pages 143-144Publisher
INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
DOI: 10.5582/ddt.2020.03046
Keywords
COVID-19; cytokine storm; lymphocyte; Kv1.3-channels; chloroquine
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Funding
- MEXT KAKENHI Grant [16K08484]
- Salt Science Research Foundation [2028]
- Tojuro Iijima Foundation for Food Science and Technology [2019-12]
- National Institute for Physiological Sciences [19-305]
- Grants-in-Aid for Scientific Research [16K08484] Funding Source: KAKEN
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In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In chronic inflammatory diseases, the overexpression of delayed rectifier K+-channels (Kv1.3) in leukocytes is responsible for the overactivation of cellular immunity and the subsequent cytokine storm. In our previous basic studies, drugs including chloroquine and azithromycin strongly suppressed the channel activity and pro-inflammatory cytokine production from lymphocytes. These findings suggest a novel pharmacological mechanism by which chloroquine, with or without azidunmycin, is effective for severe cases of COVID-19, in which the overactivation of cellular immunity and the subsequent cytokine storm are responsible for the pathogenesis.
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