Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 28, Pages 5388-5399Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01049a
Keywords
-
Categories
Funding
- NSFC [21772069, 21831007]
- TAPP, Six Kinds of Talents Project [SWYY-025]
- Graduate Students Project of Jiangsu Province [KYCX19_006]
Ask authors/readers for more resources
A catalytic asymmetric (4 + 2) cyclization ofortho-hydroxyphenyl-substitutedpara-quinone methide derivatives with 3-vinylindoles has been established in the presence of chiral phosphoric acid, which provides a series of chiral chroman derivatives bearing an indole moiety in generally high yields (up to 97%), and with good enantioselectivities (up to 90% ee) and moderate to good diastereoselectivities (up to 95 : 5 dr). This reaction has not only fulfilled the need of developing catalytic asymmetric (4 + 2) cyclizations ofpara-quinone methide derivatives with electron-rich alkenes, but also provided a useful method for constructing chiral chroman scaffolds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available