Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 18, Issue 3, Pages 221-225Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0000000000000164
Keywords
brown adipose tissue; cancer cachexia; mitochondria; muscle wasting; phosphorylation
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Funding
- Ministerio de Ciencia y Tecnologia [SAF 26091-2011]
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Purpose of reviewThe aim of the present review is to examine the impact of mitochondrial dysfunction in cancer cachexia.Recent findingsOxidative pathways are altered in this tissue during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling.SummaryAn alteration of energy balance is the immediate cause of cachexia. Both alterations in energy intake and expenditure are responsible for the wasting syndrome associated with different types of pathological conditions, such as cancer. Different types of molecular mechanisms contribute to energy expenditure and, therefore, involuntary body weight loss, one of which is mitochondrial dysfunction.
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