Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 25, Issue -, Pages 27-35Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2014.12.016
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Funding
- United States National Institutes of Health Pathways to Independence Award [5R00GM087551]
- Searle Scholar Award [11-SSP-202]
- David and Lucile Packard Foundation
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Metallopeptide catalysts and artificial metalloenzynnes built from peptide scaffolds and catalytically active metal centers possess a number of exciting properties that could be exploited for selective catalysis. Control over metal catalyst secondary coordination spheres, compatibility with library based methods for optimization and evolution, and biocompatibility stand out in this regard. A wide range of unnatural amino acids (UAAs) have been incorporated into peptide and protein scaffolds using several distinct methods, and the resulting UAAs containing scaffolds can be used to create novel hybrid metal-peptide catalysts. Promising levels of selectivity have been demonstrated for several hybrid catalysts, and these provide a strong impetus and important lessons for the design of and optimization of hybrid catalysts.
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