Journal
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
Volume 68, Issue 8, Pages 941-951Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09637486.2017.1318116
Keywords
10-Hydroxy-cis-12-octadecenoic acid; gut microbial metabolite; atopic dermatitis; intestinal microbiota
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Funding
- Japanese Ministry of Education, Science, Sports and Culture
- Bio-Oriented Technology Research Advancement Institution of Japan
- Science and Technology Promotion Program for Agriculture Forestry, Fisheries, and Food Industry of the Ministry of Agriculture, Forestry, and Fisheries of Japan
- Advanced Low Carbon Technology Research and Development Program of Japan
- NEDO Innovation Commercialization Venture Support Project
- NITTO PHARMA
- Grants-in-Aid for Scientific Research [15H02441] Funding Source: KAKEN
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The present study investigated the antiallergic and anti-inflammatory effects of 10-hydroxy-cis-12-octadecenoic acid (HYA), a novel gut microbial metabolite of linoleic acid, in NC/Nga mice, a model of atopic dermatitis (AD). Feeding HYA decreased the plasma immunoglobulin E level and skin infiltration of mast cells with a concomitant decrease in dermatitis score. HYA feeding decreased TNF- and increased claudin-1, a tight junction protein, levels in the mouse skin. Cytokine expression levels in the skin and intestinal Peyer's patches cells suggested that HYA improved the Th1/Th2 balance in mice. Immunoglobulin A concentration in the feces of the HYA-fed mice was approximately four times higher than that in the control mice. Finally, denaturing gradient gel electrophoresis of the PCR-amplified 16S rRNA gene of fecal microbes indicated the modification of microbiota by HYA. Taken together, the alterations in the intestinal microbiota might be, at least in part, associated with the antiallergic effect of HYA.
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