Journal
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
Volume 53, Issue 3, Pages 599-607Publisher
WILEY
DOI: 10.1111/ijfs.13633
Keywords
Cholesterol; dark tea; hyperlipidemia; hypolipidemic; tea polysaccharides
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Funding
- National Natural Science Foundation of China [31660493]
- Guangxi Province Science and Technology Development Program [159832-05]
- Nanning Science and Technology Development Program [20161266]
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Polysaccharides-rich dark tea is believed to be beneficial to health in Southeast Asian. However, the hypolipidemic effect of Chinese Liupao tea polysaccharides (CLTPS) has not been investigated. Here, the potential mechanism by which the oral administration of CLTPS affects lipid metabolism was evaluated using high-fat diet-induced hyperlipidemia rats. In rats supplemented with CLTPS, a suppressive effect on body weight was observed after 4weeks of intervention. CLTPS significantly improved the levels of lipid profiles, the oxidation of lipids and antioxidant enzyme activity in a dose-dependent manner. The cholesterol-lowering action was paralleled by the stimulation of cholesterol converted to bile acids along with a 1.5-fold increase in faecal excretion. Besides, the prolongation of coagulation factors and the reduction in fibrinogen content showed that CLTPS regulated the coagulation initiated through the intrinsic pathway. With current findings, CLTPS may be valuable as a natural hypolipidemic nutraceutical for human consumption.
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