Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 34, Issue -, Pages 23-30Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2015.04.003
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Funding
- NIH [1DP2GM105437-01]
- Searle Scholars Program [12-SSP-217]
- NSF CAREER Award [1253035]
- Direct For Mathematical & Physical Scien
- Division Of Physics [1253035] Funding Source: National Science Foundation
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The cell nucleus contains a large number of membrane-less bodies that play important roles in the spatiotemporal regulation of gene expression. Recent work suggests that low complexity/disordered protein motifs and repetitive binding domains drive assembly of droplets of nuclear RNA/protein by promoting nucleoplasmic phase separation. Nucleation and maturation of these structures is regulated by, and may in turn affect, factors including post-translational modifications, protein concentration, transcriptional activity, and chromatin state. Here we present a concise review of these exciting recent advances, and discuss current and future challenges in understanding the assembly, regulation, and function of nuclear RNA/protein bodies.
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