The same but different: signaling pathways in control of endothelial cell migration

The coordinated migration of endothelial cells (ECs) plays a pivotal role not only in the assembly of the embryonic vasculature, but also during various physiological and pathological processes, such as tissue regeneration and wound healing. Recent reports studying EC migration in distinct vascular beds have revealed common principles, but also surprising differences, in the molecules ECs use to ensure proper migratory behaviors. In addition to genetic cues, hemodynamic forces in perfused blood vessels also affect EC migration, thereby contributing to blood vessel remodeling. In this review, we will discuss the distinct molecules guiding EC migration in different tissues and highlight their modes of action.