Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 33, Issue -, Pages 35-41Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2014.10.008
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Funding
- Swiss National Science Foundation [31003A-141068/1]
- La ligue Genevoise contre le cancer
- Sinergia [CRSII3_147637/1]
- iGE3
- State of Geneva
- Medical Research Council UK
- Deutsche Forschungsgemeinschaft [BE5103/1-1]
- Swiss National Science Foundation (SNF) [31003A_141068, CRSII3_147637] Funding Source: Swiss National Science Foundation (SNF)
- Medical Research Council [MC_U105663139] Funding Source: researchfish
- MRC [MC_U105663139] Funding Source: UKRI
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Pyruvate metabolism plays a pivotal role in cell homeostasis and energy production. Pyruvate, the end product of glycolysis, is either catabolized in the cytosol, or enters into mitochondria to promote oxidative phosphorylation. The import of pyruvate into mitochondria requires a specific carrier in the inner mitochondrial membrane, the mitochondrial pyruvate carrier (MPC), whose identity was only recently discovered. Here we report our current knowledge of the structure and function of the MPC and we describe how dysfunction of the MPC could participate in various pathologies, including type 2 diabetes and cancer.
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