Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 35, Issue -, Pages 131-136Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2015.05.002
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Funding
- CIHR [9208, 53326]
- National Institutes of Health [P50 GM076547, U54 GM103511, U01 GM098256, R01 GM112108]
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Peroxisomes are remarkably responsive organelles. Their composition, abundance and even their mechanism of biogenesis are influenced strongly by cell type and the environment. This plasticity underlies peroxisomal functions in metabolism and the detoxification of dangerous reactive oxygen species. However, peroxisomes are integrated into the cellular system as a whole such that they communicate intimately with other organelles, control signaling dynamics as in the case of innate immune responses to infectious disease, and contribute to processes as fundamental as longevity. The increasing evidence for peroxisomes having roles in various cellular and organismal functions, combined with their malleability, suggests complex mechanisms operate to control cellular dynamics and the specificity of cellular responses and functions extending well beyond the peroxisome itself. A deeper understanding of the functions of peroxisomes and the mechanisms that control their plasticity could offer opportunities for exploiting changes in peroxisome abundance to control cellular function.
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