Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 36, Issue -, Pages 48-53Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2015.07.002
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Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [1R21HD076173-01A1]
- National Institute of General Medical Sciences [1R01GM107385-01A1, 1R33GM114257-01]
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In this review, we highlight recent re-evaluations of the classical cell sorting models and their application to understanding embryonic morphogenesis. Modern genetic and biophysical techniques reveal that tissue self-assembly is not solely a result of differential adhesion, but rather incorporates dynamic cytoskeletal tension and extracellular matrix assembly. There is growing evidence that these biomechanical modules cooperate to organize developing tissues. We describe the contributions of Cadherins and Integrins to tissue assembly and propose a model in which these very different adhesive regimes affect the same outcome through separate but convergent mechanisms.
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