Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 36, Issue -, Pages 183-188Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2015.08.018
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Funding
- Office of Energy Efficiency and Renewable Energy, United States Department of Energy
- Bioenergy Technologies Office, WBS, United States Department of Energy [2.3.2.102]
- Office of Science, Office of Biological & Environmental Research, United States Department of Energy [DE-SC-0012658]
- Office of Science
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Recent advances in metabolic engineering have facilitated the development of microbial biocatalysts capable of producing an array of bio-products, ranging from fuels to drug molecules. These bio-products are commonly generated through an acetyl-CoA intermediate, which serves as a key precursor in the biological conversion of carbon substrates. Conventional biocatalytic upgrading strategies proceeding through this route are limited by low carbon efficiencies, in large part due to carbon losses associated with pyruvate decarboxylation to acetyl-CoA. Bypass of pyruvate decarboxylation offers a means to dramatically enhance carbon yields and, in turn, bioprocess economics. Herein, we discuss recent advances and prospects for employing the phosphoketolase pathway for direct biosynthesis of acetyl-CoA from carbon substrates, and phosphoketolase-based metabolic engineering strategies for carbon efficient biocatalysis.
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