Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 32, Issue -, Pages 163-170Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2014.12.008
Keywords
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Funding
- Austrian Science Fund FWF [11103]
- Austrian Science Fund (FWF) [I 1103] Funding Source: researchfish
- Austrian Science Fund (FWF) [I1103] Funding Source: Austrian Science Fund (FWF)
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The production of high-value proteins in plants is maturing, as shown by the recent approval of innovative products and the latest studies that showcase plant-based production systems using technologies and approaches that are well established in other fields. These include host cell engineering, medium optimization, scalable unit operations for downstream processing (DSP), bioprocess optimization and detailed cost analysis. Product-specific benefits of plant-based systems have also been exploited, including bioencapsulation and the mucosal delivery of minimally processed topical and oral products with a lower entry barrier than pharmaceuticals for injection. Success stories spearheaded by the FDA approval of Elelyso developed by Protalix have revitalized the field and further interest has been fueled by the production of experimental Ebola treatments in plants.
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