Journal
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
Volume 30, Issue 3, Pages 279-284Publisher
BEGELL HOUSE INC
DOI: 10.1615/CritRevEukaryotGeneExpr.2020034380
Keywords
histone deacetylases; HDAC3; malignant tumors; proliferation; apoptosis; metastasis; angiogenesis; anticancer drug resistance
Funding
- National Natural Science Foundation of China [81602264]
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Histone deacetylases 3 (HDAC3) is a member of the histone deacetylases family. This family is associated with cellular physiological function, such as signal transduction, cell cycle, proliferation, apoptosis, and cardiac devel-opment. HDAC3 plays an important role in the progression of malignant tumors, especially in terms of proliferation, apoptosis, metastasis, angiogenesis, and anticancer drug resistance. This review discusses the basic elements of HDAC3 and the relationship between HDAC3 and malignant tumors.
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