Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 29, Pages 5582-5585Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob00226g
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Funding
- ERASMUS European program
- Region Centre Val-de-Loire
- CNRS
- LABEX Synorg [ANR-11-LABX-0029]
- University of Orleans
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The beta-d-glucuronidaseDtGlcA fromDictyoglomus thermophilumwas engineered to generate an active thioglycoligase that is able to catalyse the formation of numerousS-glucuronides. Its X-ray structure analysis indicated the ability of the biocatalyst to bind aromatic thiol acceptors forS-glycosylation. Noteworthily, theDtGlcA mutant was found to be the first thioligase that is able to use a natural sugar donor different from the widely used syntheticpara-nitrophenyl glycosides.
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