Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 29, Pages 5608-5616Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01277g
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Funding
- SERB [CRG/2018/004020]
- DBT [BT/PR15214/BRB/10/1449/2015, BT/RLF/Re-entry/45/2015]
- DST-SERB [ECR/2016/000913]
- IIT Gandhinagar
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Lipid droplets (LDs), the lipid-rich intracellular organelles, serve to regulate many physiological processes and therefore attention has been attracted towards their selective detection. We report positively solvatochromic lipophilic dyes, based on the push-pull framework containing coumarin-pyridine heterocycles for selective live-cell imaging of lipid droplets (LDs) in Cos-7 and McA-RH7777 cells at ultralow concentrations (200 nM). The fluorescent probes show a remarkable increase in fluorescence intensity with time with the hydrophobic core of the lipid droplets contributing to the observed intensity enhancement. The simple structural framework, red emission, strong Stokes shift (>80 nm), and excellent biocompatibility highlight their significance as a versatile imaging tool for studying lipid droplets (LDs).
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