Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 31, Issue -, Pages 50-56Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2014.07.011
Keywords
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Funding
- Biotechnology and Biological Sciences Research Council [BB/I017011/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K038648/1] Funding Source: researchfish
- BBSRC [BB/I017011/1] Funding Source: UKRI
- EPSRC [EP/K038648/1] Funding Source: UKRI
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With the current wealth of transcriptomic data, it is possible to design genetically-encoded biosensors for the detection of stress responses and apply these to high-throughput bioprocess development and monitoring of cellular health. Such biosensors can sense extrinsic factors such as nutrient or oxygen deprivation and shear stress, as well as intrinsic stress factors like oxidative damage and unfolded protein accumulation. Alongside, there have been developments in biosensing hardware and software applicable to the field of genetically-encoded biosensors in the near future. This review discusses the current state-of-the-art in biosensors for monitoring cultures during biological manufacturing and the future challenges for the field. Connecting the individual achievements into a coherent whole will enable the application of genetically-encoded biosensors in industry.
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