Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 61, Pages 8671-8674Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc03619f
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Funding
- National Natural Science Foundation of China [21625203, 21871126, 21901100]
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A visible light initiated alpha-C(sp(3))-H arylation ofN-(benzyloxy)phthalimides with cyanopyridines for the construction of highly valuable pyridinyl-containing diarylmethanols, including bioactive motif-based analogues, is reported. This method enables arylation of the C(sp(3))-H bonds adjacent to an oxygen atom through alkoxy radical formation by O-N bond cleavage, 1,2-hydrogen atom transfer (HAT), arylation and C-CN bond cleavage cascades, and offers a means to exploit 1,2-HAT modes to incorporate functional groups for constructing functionalized alcohols.
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