Journal
RESPIRATORY RESEARCH
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12931-020-01455-4
Keywords
COVID-19; SpO(2); FiO(2); Joint model; Prognostic marker
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Funding
- National Key R&D Program of China [2019YFC1711000]
- National Natural Science Foundation of China [81973145]
- Double First-Class University project [CPU2018GY09]
- Science Foundation of Jiangsu Commission of Health [H2018117]
- Emergency Project for the Prevention and Control of the Novel Coronavirus Outbreak in Suzhou [SYS2020012]
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Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO(2)/FiO(2)) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO(2)/FiO(2)was evaluated by jointly modeling the longitudinal responses of SpO(2)/FiO(2)and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO(2)/FiO(2)from the first to second measurement for non-survivors was observed, and a strong association between square root SpO(2)/FiO(2)and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56-2.13). Conclusions The current study suggested that SpO(2)/FiO(2)could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.
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